Miliary Tuberculosis with Extrapulmonary Tissue Involvement

Imaging in patients diagnosed with TB can help detect possible extrapulmonary involvement early, preventing neurological impairment and other complications by prompt initiation of therapy.

Memi? KB et al. – Miliary Tuberculosis

Kemal Bu?ra Memi?[1], Bircan Beyza Korkmaz[1]  and Sonay Ayd?n[1]

[1]. Erzincan University, School of Medicine, Department of Radiology ,Erzincan, Turkey.

Corresponding author: Kemal Bugra Memis, MD e-mail: kemalbugramemis@gmail.com

Authors’ contribution

KBM: Conception and design of the study, Acquisition of data, Supervision, Materials, Data collection, Writing, Final approval of the version to be submitted, Critical review contribution type; BBK: Conception and design of the study, Materials, Final approval of the version to be submitted, Literature review, Writing; SA: Conception and design of the study, Analysis and interpretation of data, Drafting the article, Final approval of the version to be submitted, Writing, Critical review contribution type.

Conflict of Interest

The authors declare no conflict of interest.

Financial Support

This research received no external funding.

Orcid

Kemal Bugra Memis: https://orcid.org/0009-0007-6746-3906

Bircan Beyza Korkmaz : https://orcid.org/0009-0006-2665-8232

Sonay Ayd?n: https://orcid.org/0000-0002-3812-6333

A 37-year-old male patient visited the emergency department complaining of a cough. Thoracic computed tomography revealed the presence of widespread nodules, measuring 1-2 mm in diameter, with a miliary pattern in both lungs (Figure 1). After a diagnosis of miliary tuberculosis (TB) was confirmed through sputum culture, antituberculosis medication was initiated. During a noncontrast brain magnetic resonance imaging (MRI) scan conducted when the patient had a headache and tinnitus, several nodular lesions of different sizes were observed in the supratentorial and infratentorial white matter. These lesions, accompanied by edema, were identified as tuberculomas (Figure 2). Noncontrast lumbar MRI was performed because the patient complained of lower back pain, revealing the presence of spondylodiscitis at the L3-L5 level, which is indicative of Pott’s disease and can lead to spinal canal compression (Figure 3).

TB is an infectious disease caused by Mycobacterium tuberculosis, which spreads through airborne particles. Although it primarily affects the respiratory system, it can also affect many other organs and systems of the body1. Brain tuberculoma is a granulomatous mass resulting from the hematogenous spread of TB. It is the most severe form of extrapulmonary TB2. Spinal TB has an insidious onset and commonly affects the thoracolumbar vertebrae and can lead to deformities and neurological deficits in complicated cases3. Imaging in patients diagnosed with TB can help detect possible extrapulmonary involvement early, preventing neurological impairment and other complications by prompt initiation of therapy.

Acknowledgements

The authors thank the research staff at the Radiology Department of Erzincan University for their valuable assistance.

References

1. Burrill J, Williams CJ, Bain G, Conder G, Hine AL, Misra RR. Tuberculosis: a radiologic review. Radiographics. 2007;27(5):1255-73.
2. Shankar GS, Nair S, Jacob T, Idikula MJ. Brain tuberculoma: a 52-year-old woman case report. Access Microbiol. 2023;5(10):000634.v4.
3. Kubihal V, Sharma R, Krishna Kumar RG, Chandrashekhara SH, Garg R. Imaging update in spinal tuberculosis. J Clin Orthop Trauma. 2021;25:101742.

FIGURE 1: Axial noncontrast thoracic computed tomography image showing multiple micronodules randomly distributed in the bilateral lungs (miliary nodular pattern).

FIGURE 2: Axial T2-weighted (T2W) (A, D), axial fluid attenuated inversion recovery (FLAIR) (B, E), sagittal (C), and coronal (F) T2W brain magnetic resonance (MR) images showing lesion foci with a centrally hypointense and peripheral hyperintense signal intensity (red arrows), which are numerous at the supra and infratentorial levels, most of which are subcortical, accompanied by peripheral vasogenic edema (yellow arrows) in some regions.

FIGURE 3: Noncontrast sagittal T1-wighted (T1W) (A) and T2-weighted (T2W) (B) lumbar magnetic resonance (MR) images show cortical irregularities accompanied by peripheral medullary bone marrow edema (red arrows) in the end plates adjacent to the L3-L4 and L4-L5 intervertebral discs. In addition, there are heterogeneous T2 signal increases in defined intervertebral discs. An abscess collection narrowing the spinal canal is also observed adjacent to the posterior corpus of the L4 vertebra (yellow arrows).