Case of severe bullous cutaneous anthrax case

Appearance of the lesions at (A) 1 month, (B) 2 months, and (C) 3 months of follow-up

Aydin NN and Aydin M – Cutaneous anthrax

Nurten Nur Aydin[1] and Murat Aydin[1]

[1]. Erzurum Regional Training and Research Hospital, Infectious Diseases and Clinical Microbiology department, Erzurum, Turkey.

Corresponding author: Nurten Nur Aydin. e-mail: nurtennurkenc@hotmail.com

Authors’ contribution

NNA: Conception and design of the study, Acquisition of data Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Supervision, Validation, Visualization, Writing-original draft, Writing-review & editing, Final approval of the version to be submitted.

MA: Final approval of the version to be submitted; Writing-review & editing.

Conflict of Interest

We have no conflict of interest.

Financial Support

We have not any financial support.

Orcid

Nurten Nur Aydin: https://orcid.org/0000-0003-4138-2490

Murat Aydin: https://orcid.org/0000-0002-0167-0802

Received 5 March 2023 – Accepted 27 April 2023

A 57-year-old man presented with swelling and a painless wound on the left arm. He was engaged in animal husbandry, and 10 days prior to this presentation, he had slaughtered a sick animal. A black, 2-cm ulcerative lesion was observed on his left forearm. No pathogens were detected in the culture obtained from the lesion. A real-time polymerase chain reaction assay of the serum sample showed Bacillus anthracis.

Additionally, meropenem, linezolid, and ciprofloxacin were administered to him. On the 3rd day of treatment, bullae of various sizes developed around the lesion, and edema progressed significantly (Figure 1). Methylprednisolone 100 mg/day was included in his medications. The edema and bullae spread to his entire arm and the back (Figure 2). Treatment was completed within 21 days. The appearance of the lesions during follow-up is shown in Figure 3.

Anthrax is a zoonotic disease caused by Bacillus anthracis, a Gram-positive toxigenic endospore-forming bacillus. Its natural hosts are herbivores from which humans acquire diseases through incidental contact with infected animals or animal products1. This case demonstrates the importance of prompt diagnosis, timely initiation of appropriate antibiotic therapy, and supportive measures, including corticosteroids, in managing severe cutaneous anthrax. In some cases, steroids may control severe inflammation, particularly in patients with significant edema, involvement of the head and neck region, or anthrax meningitis2,3.

Further studies are warranted to elucidate the optimal management strategies for severe bullous cutaneous anthrax and guide clinical decision-making in similar cases.

Acknowledgments

No.

References

1. Kamal SM, Rashid AK, Bakar MA, Ahad MA. Anthrax: an update. Asian Pac J Trop Biomed. 2011;1(6):496–501.
2. Hendricks KA, Wright ME, Shadomy SV, Bradley JS, Morrow MG, Pavia AT, et al. Centers for disease control and prevention expert panel meetings on prevention and treatment of anthrax in adults. Emerg Infect Dis. 2014;20(2):e130687.
3. Demirdag K, Ozden M, Saral Y, Kalkan A, Kilic SS, Ozdarendeli A. Cutaneous anthrax in adults: a review of 25 cases in the eastern Anatolian region of Turkey. Infection. 2003;31(5):327-30.

FIGURE  1: Multiple bullous lesions and edema seen on the third day of treatment

FIGURE 2: Appereance of cyanotic extremity (A), edema and bullae spread to the entire arm (B), and back (C)

FIGURE 3: Appearance of the lesions at (A) 1 month, (B) 2 months, and (C) 3 months of follow-up.